Retinopathy of Prematurity (ROP) Treatment in Singapore

Retinopathy of Prematurity (ROP) is an eye condition that affects some premature babies and, if not detected and treated early, can lead to serious vision problems. With timely screening, close monitoring, and appropriate treatment, most babies with ROP can preserve good vision.

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What Is Retinopathy of Prematurity (ROP)?

Retinopathy of Prematurity (ROP) is a potentially blinding eye disorder that affects premature infants, particularly those:

  • Born before 32 weeks of pregnancy
  • With a birth weight of 1500 grams or less
  • Who needed prolonged oxygen therapy after birth

ROP affects the retina, the light-sensitive layer at the back of the eye that is essential for vision. The smaller and more premature a baby is at birth, the higher the risk of developing ROP.

Why Does ROP Develop in Premature Babies?

In a full-term pregnancy, the blood vessels in the retina complete their development just before birth. When a baby is born prematurely, this normal development is interrupted.

Outside the womb, retinal blood vessels may:

  • Grow abnormally
  • Become fragile and swollen
  • Extend into the vitreous (the jelly-like centre of the eye)

In more severe cases, these abnormal vessels can bleed, form scar tissue, and pull the retina away from the back of the eye, causing retinal detachment, a serious condition that can lead to permanent vision loss if untreated.

Do All Premature Infants Develop ROP?

No. Not all premature babies develop ROP.

Babies most at risk are those who:

  • Weigh 1500 grams or less
  • Are born before 32 weeks
  • Are very ill or require intensive neonatal care

The more premature and medically fragile the infant, the higher the risk. Advances in neonatal care mean more premature babies survive today, which is why ROP screening is now routine and essential.

When and How Is ROP Screening Done?

Babies who meet screening criteria are usually examined 4–6 weeks after birth.

This is what parents can expect to happen during a ROP screening:

  • Eye drops are used to gently dilate the pupils
  • A paediatric ophthalmologist examines the retina using specialised equipment
  • The examination allows the doctor to assess blood vessel growth and detect early signs of ROP

While the process may look uncomfortable, it is brief and carefully performed, with your baby’s safety and comfort as the top priority.

How Does Retinopathy of Prematurity Progress?

ROP is classified based on location (zones) and severity (stages). The lower the zone (i.e. zone I), the closer the abnormal vessels are to the centre of the retina, and therefore the higher the threat to vision. ROP severity is classified into 5 stages, with stage 1 being the mildest form and stage 5 being the most severe.

Stages

  • Stage 1: Mild changes
  • Stage 2: Moderate changes
  • Stage 3: Severe abnormal vessel growth
  • Stage 4: Partial retinal detachment
  • Stage 5: Total retinal detachment

Doctors also assess for “plus disease”, which refers to severely dilated and twisted retinal blood vessels. Plus disease signals rapid progression and the need for urgent treatment.

How Is ROP Treated?

Observation and Monitoring

  • Stages 1 and 2 often resolve on their own
  • Close follow-up is essential to detect progression early

Laser Treatment

  • Required for Stage 3 ROP in high-risk zones or with plus disease
  • Laser therapy treats the abnormal peripheral retina to stop harmful vessel growth
  • This is the standard and proven treatment for advanced ROP

Anti-VEGF Injection Into The Eyeball

  • Certain stages of ROP may benefit from intravitreal injections of medications in the anti-VEGF group.

Surgery for Advanced ROP

  • Stages 4 and 5 involve retinal detachment
  • Surgery may be required to try to preserve vision
  • Advanced ROP is now uncommon when screening and treatment are done on time

What If Treatment Does Not Fully Work?

Laser treatment and anti-VEGF injections significantly reduces the risk of severe vision loss, but it does not guarantee perfect vision in every case. A small number of very premature or critically ill infants may still experience progression despite timely care.

This is why regular follow-up appointments are crucial, even after treatment appears successful.

Long-Term Eye Care After ROP

Children born prematurely, especially those who had ROP, are at higher risk of developing:

Even after ROP has resolved, ongoing eye examinations are essential to support healthy visual development through childhood.

Our Paediatric Eye Specialists Singapore

Dr Zena Lim

Medical Director, Consultant Ophthalmologist

Dr Kelvin Teo

Senior Consultant Ophthalmologist

Dr Loh Kai-Lyn

Senior Consultant Ophthalmologist

Disclaimer:

The information on the The Children’s Eye & ENT Centre website is intended for educational use. It should not be considered or used as a substitute for medical advice, diagnosis or treatment from a qualified health professional.